Turmeric—or additional specifically its key bioactive compound, curcumin—is one particular of the most preferred nutraceuticals in use today. In reality, a report1 by Grand View Investigate predicted that the worldwide curcumin sector will reach $94.3 million by 2022. This is steady with a additional current report from World-wide Current market Insights2, whose info predicts the global curcumin sector will exceed $145 million by 2027.
Why is curcumin so well-liked? Like vitamin D, curcumin is 1 of these nutraceuticals for which investigation suggests a wide assortment of opportunity rewards. Furthermore, turmeric has been applied as a common cure in Chinese and Indian Ayurvedic medication for over 2,000 years3, and the authors of a textbook on bioactive meals show that “the use of turmeric in Indian folk medicine is 1 of a veritable panacea, apparently efficacious for circumstances that we would at present classify in the realm of infectious, inflammatory, metabolic, and immunological health conditions.”4
1 of curcumin’s lesser-recognized positive aspects is its results on pressure/anxiousness and slumber.
How can curcumin assistance regulate worry/stress and anxiety and snooze? The response is serotonin. Serotonin is a neurotransmitter that stabilizes our temper, emotions of nicely-being, and joy. This neurotransmitter also will help with sleeping, eating, and digestion.
As it turns out, in animal research, curcumin supplementation was found to enhance serotonin degrees.5 In a single review6, chronically pressured rats ended up supplemented with curcumin. Curcumin considerably prevented the strain-induced decrease in serotonin, serving to to defeat stress-induced behavioral abnormalities. In another rat study, curcumin supplementation assisted restore serotonin balance when alcoholic beverages intake experienced adversely afflicted it.7
Persistent exposure to anxiety is a nicely-recognised risk aspect for the improvement of mood and nervousness diseases. Scientists analyzed8 the efficacy of curcumin in advertising and marketing resilience to long-term social tension in mice. The curcumin administration developed a 4.5-fold enhance in stress resilience in the the greater part of mice. These mice also introduced significantly less corticosterone (a strain hormone) following acute restraint pressure, and had decreased degrees of peripheral IL-6 (an inflammatory compound). Curcumin also prevented stress and anxiety-like behavior.
The effects of curcumin (1 g/working day) or placebo were also analyzed on the frequency of signs or symptoms of panic and depression in 30 obese human subjects in a 30-day, double-blind, crossover demo.9 Severity of anxiousness and despair was assessed at baseline and at weeks 4, 6, and 10 of the demo utilizing the Beck Anxiousness Stock and Beck Despair Inventory, both scientifically validated assessment questionnaires. Success showed that stress scores were appreciably lessened following curcumin treatment (P=.03).
Very similar benefits had been observed in other investigation, which includes studies on:
- 80 mg of nano-curcumin displaying effectiveness in lowering depression and stress and anxiety scores in people with diabetic polyneuropathy10
- 500-1000 mg of curcumin and blended curcumin/saffron displaying success in lessening depression and nervousness symptoms in people today with major depressive dysfunction11
- 1 g of curcumin demonstrating anti-anxiety impact in people with being overweight12
- 1000 mg of curcumin furthermore 10 mg of piperine demonstrating considerably bigger lessened anxiousness and melancholy symptoms as an increase-on to regular treatment in patients with big depressive disorder13
A randomized, double-blind, placebo-managed demo14 was carried out to confirm the effects of 1000 mg/day curcumin or placebo on high quality of lifetime (QoL) in 58 sufferers aged 20-70 many years with liver cirrhosis. In contrast with baseline, in general QoL scores improved significantly (P < 0.05) after curcumin administration. Furthermore, curcumin helped significantly reduce (P < 0.05) the following: sleeping during the day, decreased sexual interest, and decreased sexual activity.
Another study15 was conducted to examine the effect of turmeric supplementation on quality of life (QoL) and hematological parameters in 60 breast cancer patients on chemotherapy. Turmeric supplementation for 21 days resulted in clinically relevant and statistically significant improvement in global health status symptom scores, including fatigue and insomnia.
Although known mostly for its anti-inflammatory effects, curcumin clearly has value for positively impacting stress/anxiety and sleep due at least in part to its ability to increase serotonin levels.
Gene Bruno, MS, MHS, RH (AHG) possesses 42 years of dietary supplement industry experience. With a master’s degree in nutrition and a second master’s degree in herbal medicine, he has a proven track record of formulating innovative, evidence-based dietary supplements. Bruno currently serves as both the vice president of scientific and regulatory affairs at NutraScience Labs (Farmingdale, NY) and professor of nutraceutical science at Huntington University of Health Sciences (Knoxville, TN).
- PR Newswire press release. “Curcumin Market Is Anticipated to Grow to $94.3 Million By 2022: Grand View Research, Inc.” Published June 22, 2015.
- Global Market Insights report. “Curcumin Market Size to Exceed $145 Mn by 2027.” Published July 14, 2021.
- “Curcuma longa (turmeric). Monograph.” Alternative Medicine Review, supplement 6 (September 2001): S62-S66
- Togni S, Appendino G. “Curcumin and Joint Health: From Traditional Knowledge to Clinical Validation.” Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases edited by Watson RR, Preedy VR Academic Press 2013: 67-81
- Kulkarni SK et al. “Antidepressant activity of curcumin: Involvement of serotonin and dopamine system.” Psychopharmacology (Berl), vol. 201, no. 3 (December 2008): 435-342
- Xu Y et al. “Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats.” Brain Research. Published online June 21, 2007.
- Jagota A et al. “The effect of curcumin on ethanol induced changes in suprachiasmatic nucleus (SCN) and pineal.” Cellular and Molecular Neurobiology, vol. 27, no. 8 (December 2007): 997-1006
- Aubry AV et al. “A diet enriched with curcumin promotes resilience to chronic social defeat stress.” Neuropsychopharmacology, vol. 44, no. 4 (March 2019):733-742
- Esmaily H et al. “An investigation of the effects of curcumin on anxiety and depression in obese individuals: A randomized controlled trial.” Chinese Journal of Integrative Medicine. Published online March 17, 2015.
- Asadi S et al. “Beneficial effects of nano-curcumin supplement on depression and anxiety in diabetic patients with peripheral neuropathy: A randomized, double-blind, placebo-controlled clinical trial.” Phytotherapy Research, vol. 34, no. 4 (April 2020): 896-903
- Lopresti AL et al. “Efficacy of curcumin, and a saffron/curcumin combination for the treatment of major depression: A randomised, double-blind, placebo-controlled study.” Journal of Affective Disorders, vol. 207 (January 1, 2017): 188-196
- Esmaily H et al. “An investigation of the effects of curcumin on anxiety and depression in obese individuals: A randomized controlled trial.” Chinese Journal of Integrative Medicine, vol. 21, no. 5 (May 2015): 332-338
- Panahi Y et al. “Investigation of the efficacy of adjunctive therapy with bioavailability-boosted curcuminoids in major depressive disorder.” Phytotherapy Research, vol. 29, no. 1 (January 2015): 17-21
- Nouri-Vaskeh M et al. “Curcumin ameliorates health-related quality of life in patients with liver cirrhosis: A randomized, double-blind placebo-controlled trial.” Complementary Therapies in Medicine. Published online February 19, 2020.
- Kalluru H et al. “Turmeric supplementation improves the quality of life and hematological parameters in breast cancer patients on paclitaxel chemotherapy: A case series.” Complementary Therapies in Clinical Practice. Published online October 13, 2020.